Prescriber's Guides

6th Edition - 9781316618134

This new edition features seven new compounds as well as information about several new formulations of existing drugs. Many important new indications are covered for existing drugs, as are updates to the profiles of the entire content and collection, including an expansion of the sections on long-acting injectable formulations of antipsychotics.

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OXCARBAZEPINE

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The goal of treatment is complete remission of symptoms (e.g., seizures, mania)
Continue treatment until all symptoms are gone or until improvement is stable and then continue treating indefinitely as long as improvement persists
Continue treatment indefinitely to avoid recurrence of mania and seizures

If It Doesn’t Work (for bipolar disorder)

Many patients have only a partial response where some symptoms are improved but others persist or continue to wax and wane without stabilization of mood
Other patients may be nonresponders, sometimes called treatment-resistant or treatment-refractory
Consider increasing dose, switching to another agent, or adding an appropriate augmenting agent
Consider adding psychotherapy
For bipolar disorder, consider the presence of noncompliance and counsel patient
Switch to another mood stabilizer with fewer side effects
Consider evaluation for another diagnosis or for a comorbid condition (e.g., medical illness, substance abuse, etc.)

Best Augmenting Combos for Partial Response or Treatment Resistance

Oxcarbazepine is itself a second-line augmenting agent for numerous other anticonvulsants, lithium, and atypical antipsychotics in treating bipolar disorder, although its use in bipolar disorder is not yet well studied
Oxcarbazepine may be a second- or third-line augmenting agent for antipsychotics in treating schizophrenia, although its use in schizophrenia is also not yet well studied

Tests

Consider monitoring sodium levels because of possibility of hyponatremia, especially during the first 3 months

acamprosate	agomelatine	alprazolam	amisulpride
amitriptyline	amoxapine	amphetamine (d)	amphetamine (d,l)
aripiprazole	armodafinil	asenapine	atomoxetine

benztropine	blonanserin	brexpiprazole	buprenorphine
bupropion	buspirone

caprylidene	carbamazepine	cariprazine	chlordiazepoxide
chlorpromazine	citalopram	clomipramine	clonazepam
clonidine	clorazepate	clozapine	cyamemazine

desipramine	desvenlafaxine	dextromethorphan	diazepam
diphenhydramine	disulfiram	donepezil	dothiepin
doxepin	duloxetine

flibanserin	flumazenil	flunitrazepam	fluoxetine
flupenthixol	fluphenazine	flurazepam	fluvoxamine

Prescriber's Guides

6th Edition - 9781316618134

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Table of Contents

Introduction

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Index by drug name

Index by use

Index by class

Abbreviations

OXCARBAZEPINE

THERAPEUTICS

lamotrigine	levetiracetam	levomilnacipran	lisdexamfetamine
lithium	lofepramine	loflazeptate	lorazepam
lorcaserin	loxapine	lurasidone

maprotiline	memantine	mesoridazine	methylfolate (l)
methylphenidate (d)	methylphenidate (d,l)	mianserin	midazolam
milnacipran	mirtazapine	moclobemide	modafinil
molindone

nalmefene	naltrexone	naltrexone-bupropion	nefazodone
nortriptyline

paliperidone	paroxetine	perospirone	perphenazine
phenelzine	phentermine-topiramate	pimavanserin	pimozide
pipothiazine	prazosin	pregabalin	propranolol
protriptyline

selegiline	sertindole	sertraline	sodium oxybate
sulpiride	suvorexant

tasimelteon	temazepam	thioridazine	thiothixene
tiagabine	tianeptine	topiramate	tranylcypromide
trazodone	triazolam	trifluoperazine	trihexyphenidyl
triiodothyronine	trimipramine

zaleplon	ziprasidone	zolpidem	zonisamide
zopiclone	zotepine	zuclopenthixol